How does it work?
LDN is best taken at night before bed. During sleep, it begins blocking opioid receptors as well as receptors of endorphins. Endorphins are opiate-like chemicals best known as the “feel good” substances the body makes after exercise. The word endorphin actually comes from 2 words: endogenous (made within the body) and morphine. Endorphins are known to block pain, are very involved with immune function and rapid cell reproduction, particularly an endorphin called Opioid Growth Factor (OGF) or Met-Enkephalin. When these receptors are blocked for a short period, the body responds by creating more receptors, increasing their sensitivity and thus making more endorphins. Once the LDN wares off, a “rebound effect” is experienced in which the amount of available OGF and its utilization is greatly enhanced having a very positive effect on immunity. It is believed, LDN can work for many different conditions, all of which are affected by immune function and tend to lead to lower levels of endorphin release.
Some of the most promising research has centered on the effects of LDN and cancer. Studies find, LDN inhibits proliferation of cancer cells and reduces tumor growth by targeting these signaling pathways and changing the immune system. Further research has found it potentiates chemotherapy drugs helping them to work better. This is an incredible breakthrough bringing hope to patients for enhanced treatment strategies.
Additionally, LDN is very useful as a prokinetic, helping the intestine to regain its natural ability to contract, mix and move food through its length. In cases of low thyroid, it’s common for intestinal movements to slow down causing bowel issues like constipation or diarrhea, gas, bloating, GERD, bacterial overgrowth and abdominal pain. For these patients, LDN can help them to resume a normal flow.
While LDN research is still underway, we currently see many possible and exciting uses for this medication. In MS trials, patients reported seeing a decrease in symptoms within the first few days of use. Not only is LDN effective, it is fast acting and has extremely low incidence of side effects. Some patients report very vivid dreams while others have some insomnia for the first week of use. Overall, LDN may be a beneficial treatment for many different conditions.